An Iberia Airbus A340-300, registration EC-HQN performing flight IB-6166 from Boston,MA (USA) to Madrid,SP (Spain), rejected takeoff from Boston's runway 22R (runway length 7861 feet/2397 meters) at high speed due to an engine #1 (CFM56, outboard left hand) indication. The crew of another aircraft reported seeing smoke from the #1 engine. The airplane vacated runway 22R turning right onto taxiway E at the end of the runway and stopped there shutting down both left hand engines to permit fire engines access the #1 engine.
Runway 22R was closed for a runway inspection for about 20 minutes.